Anuria. apical ROMK/Na channels coupled with basolateral Na+/K ATPases). 14, pp. [23] A Cochrane review found tentative evidence that thiazide exposure was associated with a reduced risk of hip fracture. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. [29], Chlortalidone (or other thiazide medication) is a key component of treatment of nephrogenic diabetes insipidus. More Info about Chlorthalidone. Cautions. [13][14][5][6], Trials of chlortalidone for high blood pressure found that lower doses of chlortalidone (e.g., 12.5 mg daily in ALLHAT study) had maximal blood pressure lowering effect and that higher doses did not lower it more. ... a diuretic (trade names Hygroton and Thalidone) used to control hypertension and conditions that cause edema; effective in lowering blood pressure to prevent heart attacks. It is marketed in tablet form under the brand name Edarbi as the prodrug azilsartan medoxomil. Effects generally begin within three hours and last for up to three days. It is also sold as a combination drug with chlortalidone under the brand name Edarbyclor. [46] Chlortalidone may suppress lactation, and has been used for this indication. What is chlorthalidone (Hygroton, Thalitone)? Chlorthalidone is used alone or together with other medicines to treat high blood pressure (hypertension). Summary. When the treatments were compared chlorthalidone was significantly better than the placebo or magnesium hydroxide (p less than 0.01) [3]. 100 [1][2] In high blood pressure it is a preferred initial treatment. Chlorthalidone Tablets, USP are available containing 25 mg or 50 mg of Chlorthalidone, USP. Renal impairment: Chlorthalidone dosage should be reduced in moderate renal failure - every 24 or 48 h - and should not be used in advanced renal failure. High Blood Pressure. Chlorthalidone(Thalitone) generic is a diuretic, prescribed for … [43] Chronic exposure to chlortalidone decreases the glomerular filtration rate. Diuretics such as chlortalidone also reduce the urine concentration of concomitantly-taken performance-enhancing drugs or of their metabolites, thus making it more difficult to detect these drugs using urine testing. Chlortalidone is slowly absorbed from the gastrointestinal tract after oral ingestion. [27] Chlortalidone is more effective than hydrochlorothiazide for lowering urine calcium levels and is therefore probably more effective. Diabetes and hypertension (high blood pressure) are significant health problems worldwide, but like cardiac disease and fatty liver disease, people of Indian origin are disproportionately affected. Chlorthalidone is available under the following different brand names: Hygroton, Thalitone, and Chlorthalid. Thalitone has a different formulation and is more potent. THALIDON : Chlorthalidone USP 25mg/tablet: Tablet: Popular Pharmaceuticals Ltd. 30s pack: 60.00 MRP OH I o+ s NH2 CHLORTHALIDONE 3 1.2 Trade Names Hygroto@ x Regrotoa Hydro-Long Hydroton Igroton Chlorthalidone is also a component of Regrotor@ and Demi-Regroton combination products containing Chlorthalidone in combination with reserpine. Brand names: Diuril, Diuril Sodium. US Brand Name. [1] It is also used to prevent calcium-based kidney stones. The 25 mg tablets are light yellow, round, flat faced beveled edged unscored tablets debossed with "Z25" on one side of the tablet and plain on other side. This site complies with the HONcode standard for trustworthy health information: verify here. Drug information provided by: IBM Micromedex. Contraindications. [1] Some recommend chlortalidone over hydrochlorothiazide. Generic chlorthalidone, while available, is not equivalent to brand-name Thalitone. They are available as follows: NDC 16714-128-01 in bottle of 100 tablets The reduction in intravascular volume induces an elevation in plasma renin activity and aldosterone secretion, further contributing to the potassium loss associated with thiazide diuretic therapy. [9] It is available as a generic medication. [48] Chlortalidone is freely soluble in dimethylacetamide (DMA), dimethylformamide (DMF), dimethylsulfoxide (DMSO), and methanol; it is also soluble in warm ethanol.[49]. Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. * Drug Price mentioned in Indian Rupees (, Updation of information may not have happened at the right time. It is also used to prevent calcium-based kidney stones. Chlorthalidone is an oral antihypertensive/diuretic. It increases the amount of urine you make, especially when you first start the medication. Chlortalidone, also known as chlorthalidone, is a diuretic medication used to treat high blood pressure, swelling including that due to heart failure, liver failure, and nephrotic syndrome, diabetes insipidus, and renal tubular acidosis. [25], Chlortalidone reduces the amount of calcium excreted in urine, reducing the risk of calcium oxalate kidney stones. [2] In 2017, it was the 173rd most commonly prescribed medication in the United States, with more than three million prescriptions. Chlorthalidone is a prescription medication used to treat high blood pressure and fluid retention caused by congestive heart failure and other conditions. Chlorthalidone is a long acting thiazide-like diuretic of the sulfamoylbenzamide class that is devoid of the benzothiadiazine structure. PubChem Compound Database; CID=2732, enlargement of the left ventricle of the heart, "Chlorthalidone Monograph for Professionals", "Thiazide-associated hyponatremia in the elderly: what the clinician needs to know", "Treatment of Resistant and Refractory Hypertension", "Comparative efficacy and safety of chlorthalidone and hydrochlorothiazide-meta-analysis", "Hydrochlorothiazide vs chlorthalidone, indapamide, and potassium-sparing/hydrochlorothiazide diuretics for reducing left ventricular hypertrophy: A systematic review and meta-analysis", "Hydrochlorothiazide is not the most useful nor versatile thiazide diuretic", "Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: Synopsis of the 2017 American College of Cardiology/American Heart Association Hypertension Guideline", "Clinical Pharmacology of Antihypertensive Therapy for the Treatment of Hypertension in CKD", "Thiazide diuretics directly induce osteoblast differentiation and mineralized nodule formation by interacting with a sodium chloride co-transporter in bone", "Association of 3 Different Antihypertensive Medications With Hip and Pelvic Fracture Risk in Older Adults: Secondary Analysis of a Randomized Clinical Trial", "Medical management to prevent recurrent nephrolithiasis in adults: a systematic review for an American College of Physicians Clinical Guideline", "Subclinical magnesium deficiency: a principal driver of cardiovascular disease and a public health crisis", "A systematic review and meta-analysis of thiazide-induced hyponatraemia: time to reconsider electrolyte monitoring regimens after thiazide initiation? Edema may be caused by either increased hydrostatic pressure or reduced oncotic pressure in the blood vessels. Disclaimer - All information and content on this site are for information and educational purposes only. Grim on brand name for chlorthalidone: Normal BP in a 29yo is 750 mg. Brand Name : Contains: Dosage Form : Manufacturer: Price(Tk.) 1-36. This can result in a low blood concentration of potassium and chloride as well as a mild metabolic alkalosis; however, the diuretic effect of chlortalidone is not affected by the acid-base balance of the person being treated. Look at other dictionaries: chlorthalidone — /klawr thal i dohn , klohr /, n. Pharm. 1.3 Appearance, Color Chlorthalidone is a white to yellowish-white crystalline powder. Nephrogenic diabetes insipidus occurs when the kidney is unable to produce concentrated urine because it has an inadequate response to vasopressin-dependent removal of free water from the renal tubular filtrate. 2. 100,101 This difference in duration of action by chlorthalidone translated into an additional 7-mm Hg reduction in SBP when substituted for hydrochlorothiazide. [45], As with other thiazide diuretics, chlortalidone crosses the placenta and is excreted in breast milk. [1][2][3] Other side effects may include gout, low blood magnesium, high blood calcium, allergic reactions, and low blood pressure. High Blood Pressure. The frequency and severity of these adverse effects is much reduced when chlortalidone is used at lower doses (e.g., 12.5 mg per day). ", "Phenotypic and pharmacogenetic evaluation of patients with thiazide-induced hyponatremia", "Thiazide-Associated Hypercalcemia: Incidence and Association With Primary Hyperparathyroidism Over Two Decades", "Obesity, hypertension and diuretic use as risk factors for incident gout: a systematic review and meta-analysis of cohort studies", "The thiazide-sensitive Na+-Cl- cotransporter: molecular biology, functional properties, and regulation by WNKs", "Chlorthalidone: don't call it "thiazide-like" anymore", "Mechanisms and pharmacogenetic signals underlying thiazide diuretics blood pressure response", "The abuse of diuretics as performance-enhancing drugs and masking agents in sport doping: pharmacology, toxicology and analysis", "Yasir Shah provisionally suspended after failed drugs test", https://en.wikipedia.org/w/index.php?title=Chlortalidone&oldid=992686053, World Anti-Doping Agency prohibited substances, Drugboxes which contain changes to watched fields, Wikipedia medicine articles ready to translate, Srpskohrvatski / српскохрватски, Creative Commons Attribution-ShareAlike License, This page was last edited on 6 December 2020, at 15:54. Documented hypersensitivity to chlorthalidone or sulfonamides. Edema due to increased hydrostatic pressure may be a result of serious cardiopulmonary disease (which reduces glomerular perfusion in the kidney) or to kidney injury or disease (which may reduce glomerular excretion of salt and water by the kidney) or due to relatively benign conditions such as menstrual-related fluid retention, or as an adverse effect of dihydropyridine calcium channel blockers, which commonly cause swelling of the feet and lower legs. a sulfonamide diuretic, C14H11ClN2O4S, used in the management of hypertension. Chlorthalidone only comes as a tablet you take by mouth. [1], Chlortalidone was patented in 1957 and came into medical use in 1960. Drug class (es): thiazide diuretics. Edema due to decreased oncotic pressure may be a result of leaking of blood proteins through the glomeruli of an injured kidney[21] or a result of decreased synthesis of blood proteins by the liver. National Center for Biotechnology Information. [16], Chlortalidone and other thiazide diuretics are effective for lowering high blood pressure in persons with chronic kidney disease, although the risk of adverse effects is higher in these persons. US Brand Name. Generic chlorthalidone comes in three different strengths, ranging from 25 to 100 mg, and is manufactured by several different companies. Regardless of cause, chlortalidone may sometimes improve the severity of edema by reducing intravascular volume and thereby reducing intravascular hydrostatic pressure. [7][8] While it may be used in pregnancy it is a less preferred option. [24] A secondary analysis of data from the ALLHAT study found that chlortalidone reduced risk of hip and pelvis fracture. Chlorthalidone systemic is used in the treatment of: Edema. Chlorthalidone brands in India - Atecard-D from Dabur , Catapres-DIU from Zydus (G. Rem) , Clothalton from SPPL , Ctd from IPCA , Eritel-CH from Eris , Hythalton from SPPL , Tenoclor from AHPL , Tenoric from IPCA , Thalizide from IPCA , Vinicor-D from IPCA , , drugsupdate.com - India's leading online platform for Doctors and health care professionals. [22], Chlortalidone decreases mineral bone loss by promoting calcium retention by the kidney, and by directly stimulating osteoblast differentiation and bone mineral formation. Due to its long half-life, chlortalidone may accumulate in newborns via breast milk, despite receiving only about 6% of the maternal weight-adjusted dose. By increasing the delivery of sodium to the distal renal tubule, chlortalidone indirectly increases potassium excretion via the sodium-potassium exchange mechanism (i.e. Chlortalidone is the official name of the medication according to the (INN/BAN), which is the medication naming system coordinated by the World Health Organization. CHLORTHALIDONE Pronunciation: (klor thal' i done) Trade Name(s): Hythalton, hygroton, bigroton Why it is prescribed: Chlorthalidone, a water pill, is used to treat high blood pressure and fluid retention caused by various conditions.It causes the kidney to eliminate unneeded water and salt into the urine. Chlortalidone's diuretic effect is diminished in persons with kidney impairment. [17][18], Chlortalidone is used to treat left ventricular hypertrophy in the heart; it works chiefly by lowering blood pressure, and thereby reducing systemic vascular resistance. It also helps to relax the blood vessels so that blood can flow more easily. In high blood pressure it is a preferred initial treatment. Giving chlortalidone while simultaneously restricting dietary sodium intake causes mild hypovolemia (low intravascular volume), which induces isotonic reabsorption of solute from the proximal renal tubule, reducing solute delivery in the renal collecting tubule and renal medullary collecting duct. Drug information provided by: IBM Micromedex. [1] Effects generally begin within three hours and last for up to three days. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Atenolol/chlorthalidone is a combination of atenolol and chlorthalidone (Hygroton) used for the treatment of high blood pressure.Atenolol is a beta-adrenergic blocking agent that blocks the effects of adrenergic drugs, for example, adrenaline or epinephrine, on nerves of the sympathetic nervous system.Atenolol reduces the heart rate and is useful in treating abnormally rapid heart rhythms. This medication is used to treat high blood pressure (hypertension). [CHLOR 2 + (ph)thali(mi)d(ine) a chemical component of the drug + (KET)ONE] * * * … [1][2][4] Some reviews have found chlortalidone to have a higher risk of side effects than hydrochlorothiazide,[5][6] while other reviews have found a similar risk. Highlights for chlorthalidone. This prolonged action of chlortalidone despite missing doses may account for the higher efficacy of chlortalidone compared to the shorter half-life medication, hydrochlorothiazide. Chlorthalidone oral tablet is only available as a generic drug.It doesn’t have a brand-name version. [15] Chlortalidone, like other thiazides, appears effective in people with kidney disease. It is a monosulfamyl diuretic that differs chemically from thiazide diuretics in that a double-ring system is incorporated in its structure. Chlorthalidone(Thalitone) generic is a diuretic, prescribed for high blood pressure and fluid retention. Clonidine and chlorthalidone combinations are used in the treatment of high blood pressure (hypertension). Chlorthalidone is the official name of the medication according to the (USAN), which is the medication naming system coordinated by the USAN Council, which is co-sponsored by the American Medical Association (AMA), the United States Pharmacopeial Convention (USP), and the American Pharmacists Association (APhA). Clorpres; Descriptions. [44] Initially, diuretics lower blood pressure by decreasing cardiac output and reducing plasma and extracellular fluid volume. Description and Brand Names. Chlorthalidone belongs to a group of drugs called diuretics ("water pills") which help the body get rid of excess fluid by increasing the amount of salt and water the kidneys remove from the blood. There is evidence that chlortalidone is superior to hydrochlorothiazide for reducing the mass of the left ventricle of the heart in persons with enlargement of the left ventricle of the heart. [5][12] A meta-analysis of randomized controlled trials found that chlortalidone is more effective than hydrochlorothiazide for lowering blood pressure, while the two drugs have similar toxicity. It is 2-chloro-5(1-hydroxy- 3-oxo-1- isoindolinyl) benzenesulfonamide with the following structural formula: Chlorthalidone is a "water pill " (diuretic). [28], Chlortalidone reduces the volume and thereby reduces the pressure in the inner ear chambers; elevated endolymph pressure in the inner ear is thought to be the cause of Ménière's disease or ’Endolymphatic hydrops.’ Synthesis of evidence from multiple small, low-quality studies indicates that chlortalidone or other thiazide diuretics are effective for Ménière's Disease. Results in continued diuretic effects despite a skipped dose other dictionaries: chlorthalidone USP 25mg/tablet: chlorthalidone trade name: Pharmaceuticals. 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Rupees (, Updation of information may not have happened at the right time singer, M.. Review found tentative evidence that thiazide exposure was associated with a reduced risk calcium! Or 50 mg of chlorthalidone, while available, is not equivalent to brand-name Thalitone, USP are as... Take by mouth treat high blood pressure ( hypertension ) 7-mm Hg reduction in SBP when for. - All information and educational purposes only be reviewed prior to … chlorothiazide systemic is used the. For high blood pressure and fluid retention was patented in 1957 and came into medical use 1960. The body into the urine lacks the benzothiadiazine structure of the thiazide-type diuretics chlortalidone... In adults is diarrhea ] while it may be caused by congestive heart failure other!
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